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Indications

Xeloda (capecitabine) is a chemotherapy medication used to treat several types of cancer, including breast cancer, colorectal cancer, and stomach cancer, among others. Some specific indications for Xeloda are:

• As adjuvant treatment in patients with stage III (Dukes’ C) colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred;
• For the treatment of metastatic breast cancer resistant to both anthracycline and taxane therapy or when anthracycline therapy is not suitable;
• As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred;
• For the treatment of advanced or metastatic gastric cancer or gastroesophageal junction adenocarcinoma in combination with platinum-containing regimens as first-line therapy, when fluoropyrimidine therapy alone is either considered inappropriate or has previously been administered.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start taking capecitabine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually twice daily (about 12 hours apart). Your doctor may direct you to take this medication in a treatment cycle. Carefully follow your doctor’s instructions.

Swallow the tablets whole with water within 30 minutes after a meal. Do not crush, chew, or split the tablets. If you have trouble swallowing the tablets whole, ask your healthcare professional for advice.

The dosage is based on your medical condition, body size, and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

If you vomit after taking a dose, do not take another dose at that time. Take your next dose at the regular time.

Side Effects

Common side effects of Xeloda:

• Fatigue/tiredness and weakness
• Loss of appetite
• Diarrhea
• Nausea and vomiting
• Mouth sores or ulcers

These side effects may vary in severity and can often be managed or mitigated with proper medical treatment and self-care.

Serious side effects include:

• Heart problems
• Liver problems
• Increased risk of bleeding
• Dehydration
• Kidney problems
• Skin reactions

Report any side effects or concerns to your healthcare provider immediately. Your healthcare provider can discuss potential side effects and guide how to manage them.

Cautions

Before taking capecitabine, tell your doctor or pharmacist if you are allergic to it; or to 5-fluorouracil; or if you have any other allergies.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain enzyme deficiency (dihydropyrimidine dehydrogenase – DPD), blood disorders (such as bone marrow suppression), heart problems (such as heart failure, coronary artery disease), kidney disease, liver problems.

Capecitabine can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, or flu). Talk to your doctor if you have been exposed to an infection or for more details.

Avoid contact with people who have recently received live vaccines (such as a flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Capecitabine may harm an unborn baby. Your doctor should order a pregnancy test before you start this medication. Women using this medication should ask about reliable forms of birth control during treatment and for 6 months after the last dose. Men using this medication should ask about reliable forms of birth control during treatment and for 3 months after the last dose. If you or your partner becomes pregnant, talk to your doctor right away about the risks and benefits of this medication.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding while using this drug is not recommended during treatment and for 1 week after the last dose. Consult your doctor before breastfeeding.

Form and Strengths

Xeloda is available in the following form and strengths:

Capecitabine Tablet:

• 150 mg
• 500 mg

FAQ

What types of cancer is Xeloda used to treat?

Xeloda is used to treat several types of cancer, including breast cancer, colorectal cancer, and stomach cancer, among others.

How is Xeloda taken?

Xeloda is available in tablet form and is taken orally.

Can Xeloda be used with other medications?

It is important to discuss all current medications and supplements with your healthcare provider before starting treatment with Xeloda.

How often do patients need to be monitored while on Xeloda?

Patients must be closely monitored for side effects, and regular blood counts taken while on Xeloda. Your healthcare provider will discuss the monitoring schedule with you before starting treatment.

Can Xeloda be used during pregnancy?

It is not recommended to use Xeloda during pregnancy or while breastfeeding. Women of childbearing age should use contraception while taking the medication.

Resources:

1. https://www.webmd.com/drugs/2/drug-7777/capecitabine-oral/details
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020896s037lbl.pdf
3. https://www.medicalnewstoday.com/articles/drugs-xeloda-dosage