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Indications

Cafergot is a prescription medication used to treat or prevent vascular headaches, including migraine and cluster headaches.

Cafergot is a combination medication that contains two active ingredients: ergotamine tartrate and caffeine. Ergotamine tartrate works by constricting blood vessel walls in the head, which helps to relieve migraine symptoms.

Caffeine helps to increase the absorption of ergotamine and may provide additional relief by constricting blood vessels elsewhere in the body.

Use and Dosage

Take this medication by mouth with or without food as directed by your doctor, usually, 2 tablets at the first sign of a headache, followed by 1 tablet every half hour until the headache is relieved. Do not take more than 6 tablets per headache attack or 10 tablets in 7 days.

If your doctor has prescribed this medication to help prevent certain types of headaches (such as cluster headaches), take this medication exactly as directed by your doctor, usually for short-term treatment (2 to 3 weeks).

The dosage is based on your medical condition and response to treatment. This medication works best if it is taken at the first sign of the headache. If you wait until the headache has worsened, the medication may not work as well.

If you have a higher risk for heart problems (see Precautions), your doctor may perform a heart exam before you start taking this medication. He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects (such as chest pain). Talk to your doctor for details.

This medication is usually taken only as needed. It is not meant for long-term daily use.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you are using drugs for migraine attacks on 10 or more days each month, the drugs may make your headaches worse (medication overuse headache). Do not use medications more often or for longer than directed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if your headaches get worse.

Side Effects

Nausea, vomiting, upset stomach, restlessness, trouble sleeping, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including slow/fast/irregular heartbeat, numbness/tingling in fingers/toes, blue fingers/toes/nails, cold hands/feet, muscle pain/weakness, severe stomach/abdominal pain, lower back pain, signs of kidney problems (such as a change in the amount of urine).

Get medical help right away if you have any very serious side effects, including chest/jaw/left arm pain, confusion, trouble speaking, vision changes, and weakness on one side of the body.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

This is not a complete list of side effects.

Cautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to ergotamine or caffeine; other ergot alkaloids (such as dihydroergotamine); or if you have any other allergies. This product may contain inactive ingredients (such as tartrazine found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (for example, in your legs, arms/hands, or stomach), certain types of headaches (hemiplegic or basilar migraine), heart problems (such as chest pain, irregular heartbeat, previous heart attack), kidney disease, liver disease, personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stroke or “mini-stroke” (transient ischemic attack).

Certain conditions can increase your risk for heart problems. Tell your doctor if you have any of these conditions, including high blood pressure, high cholesterol, diabetes, family history of heart disease, overweight, postmenopausal (women), or age more than 40 years (men).

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you dizzier. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Remember that alcohol may cause headaches.

Using tobacco/nicotine products while using this medication can increase the risk of serious side effects such as heart problems and decreased blood flow to the brain/hands/feet. Do not use tobacco while taking this medication. If you smoke, talk to your doctor about how to stop smoking.

Before having surgery or certain medical procedures (such as a heart stress test or a procedure to restore a normal heart rhythm if you have an unusually fast heartbeat), tell your doctor or dentist that you use this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication must not be used during pregnancy. It may harm an unborn baby. Discuss the use of reliable forms of birth control (such as condoms, birth control pills) with your doctor. If you become pregnant or think you may be pregnant, tell your doctor right away.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Form and Strengths

Sporanox is available in the following form and strengths:

• Sporanox Capsule:
  • 100 mg
• Itraconazole Capsule:
  • 100 mg

FAQ

How does Cafergot work?

Ergotamine tartrate works by constricting blood vessel walls in the head, which helps to relieve migraine symptoms.

Caffeine helps to increase the absorption of ergotamine and may provide additional relief by constricting blood vessels elsewhere in the body.

Is a prescription required to take Cafergot?

Yes, Cafergot is a prescription medication and should only be taken under the guidance of a healthcare professional.

Resources:

1. https://pubmed.ncbi.nlm.nih.gov/11844898/
2. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4a06de6-f837-43a8-ae7a-aadb38dd2a7d
3. https://www.webmd.com/drugs/2/drug-6706/cafergot-oral/details