Safely Buy Pradaxa ( dabigatran etesilate ) from Canada Prescriptions Plus.

Indications

Pradaxa is an anticoagulant medication used to prevent blood clots, treat deep vein thrombosis (DVT) or pulmonary embolism (PE), and lower the risk of stroke caused by blood clots in those with atrial fibrillation not caused by a heart valve problem.

Dabigatran etexilate is a direct thrombin inhibitor that inhibits platelet aggregation and vasodilation by increasing cyclic adenosine monophosphate levels through its inhibitory effects. This allows Pradaxa to offer antithrombotic effects while improving blood flow to prevent blood from clotting.

This anticoagulant is generally well-tolerated and effective as a preventative measure for stroke and systemic embolism in those with nonvalvular atrial fibrillation. Pradaxa is also associated with providing lower rates of serious adverse reactions.

Uses and Dosage

The dose of Pradaxa that is prescribed will vary depending on the individual being treated. Follow all your doctor’s instructions and read packaging labels carefully to ensure the best results during your treatment.

• Swallow capsules whole, do not crush or chew
• Take with a full glass of water
• Praxada can be taken with or without food
• Most adults take between 75 and 150mg twice daily
• To reduce risks from nonvalvular AF, most take 150mg twice daily
• To treat DVT and PE adults take 150mg twice a day
• To prevent DVT and PE after hip replacement surgery, most take 110mg for the first day and then 220mg once daily
• Tell your doctor or dentist if you have taken Pradaxa within the past 12 hours if you need surgery, medical tests, or dental work
• Do not suddenly stop taking Pradaxa
• Store at room temperature away from moisture and heat
• Do not transfer Pradaxa capsules into a pill box or organizer, leave them in their packaging
• Throw away any unused capsules after 4 months of having opened the bottle
• Throw away capsules in a blister pack after the expiration date has passed

Side Effects

Pradaxa may cause some side effects to develop while it improves your blood flow and inhibits its ability to clot. Speak with your doctor for more specific information regarding any symptoms you may encounter when taking dabigatran etexilate.

Common Pradaxa side effects:

• Stomach pain or discomfort
• Indigestion
• Nausea, diarrhea

Serious Side Effects

Some more serious adverse reactions may occur when taking dabigatran etexilate. Stop using Pradaxa and call your doctor right away if you develop any of the following side effects:

• Bleeding that won’t stop
• Headache, weakness, dizziness, or feeling like you might pass out
• Easy bruising or bleeding
• Blood in your urine or stools, black or tarry stools
• Cough with bloody mucus or vomit that looks like coffee grounds
• Pink or brown urine
• Joint pain or swelling
• Heavy menstrual bleeding

Seek immediate medical attention if you develop symptoms of a spinal blood clot. These include back pain, lower body numbness or muscle weakness, or loss of bladder or bowel control.

Allergic Reaction

Do not take Pradaxa if you are allergic to dabigatran etexilate. If you develop an allergic reaction, stop using this medication and contact your doctor right away.

Pradaxa allergy symptoms may include:

• Hives
• Pain or tightness in your chest
• Wheezing, difficulty breathing
• Swelling of face, lips, tongue, or throat

Cautions

Pradaxa can cause you to bleed more easily. Call your doctor immediately if you have bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds.

Avoid drinking alcohol while taking Pradaxa because it can increase your risk of stomach bleeding.

If you undergo a spinal tap or receive spinal anesthesia while using Pradaxa, a very serious spinal blood clot could form. The risk of this is higher if you have a genetic spinal defect, a spinal catheter, a history of spinal surgery or repeated spinal taps, or if you also use other drugs that affect blood clotting.

Do not suddenly stop taking Pradaxa because your risk of blood clotting or having a stroke will be increased. Consult with your doctor if you want to stop taking this medication.

Do not use Pradaxa if you have an artificial heart valve or active bleeding.

Dabigatran etexilate may cause you to bleed more easily, especially if you have any of the following:

• Stomach ulcer or bleeding in your stomach or intestines
• Kidney disease (especially if you also take dronedarone or ketoconazole)
• If you take medicines that increase your risk for bleeding such as aspirin, clopidogrel, or heparin
• If you take a nonsteroidal anti-inflammatory drug (NSAID) regularly such as ibuprofen, naproxen, or diclofenac
• You are older than 75

To ensure your safety when taking Pradaxa, tell your doctor if you have any of the following:

• Kidney disease
• Bleeding disorder caused by disease or genetics
• Antiphospholipid syndrome
• Stomach ulcers
• If you have been taking rifampin

Tell your doctor if you also take rifampin, amiodarone, clarithromycin, dronedarone, or ketoconazole before taking Pradaxa.

Some other drugs can interact with dabigatran etexilate and cause adverse reactions. To ensure your safety, tell your doctor about all the medications you take, including over-the-counter medicine, vitamins, and herbal products, but especially any of the following:

• Abciximab, clopidogrel, dipyridamole, eptifibatide, ticlopidine, tirofiban
• Alteplase, reteplase, tenecteplase, urokinase
• Apixaban, argatroban, bivalirudin, desirudin, lepirudin, rivaroxaban
• Dalteparin, enoxaparin, heparin, tinzaparin

Pradaxa may cause bleeding in the mother or baby when taken during pregnancy, but the risk of developing blood clots is higher during pregnancy and is important to prevent. Tell your doctor if you are pregnant or plan to become pregnant to determine a treatment plan that’s right for you.

Do not breastfeed while using Pradaxa.

Form and Strength

This anticoagulant medication is available in capsule form.

Pradaxa capsule strengths:

• 75mg
• 110mg
• 150mg

The 75mg Pradaxa capsules are available in quantities of 30 or 90 while the 110mg ones are available in groups of 60, 90, or 180, and the 150mg ones are available in quantities of 60, 100, 120, or 180.

FAQ

How does Pradaxa treat DVT and PE?

Pradaxa uses dabigatran etexilate, an anticoagulant, to thin your blood and improve its flow to prevent blood clots from forming in your legs or lungs. When taken long term it helps reduce the risk of developing blood clots in these areas and others again.

Does Pradaxa have any dietary restrictions?

No, unlike some other anticoagulant medications like warfarin, there are no limits on your diet when taking Pradaxa. You can also take your doses with or without food because its absorption is not effected either way. However, you should avoid drinking alcohol during treatment because it can increase your risk of stomach bleeding.

Resources:

1. https://pubmed.ncbi.nlm.nih.gov/28185082/
2. https://pubmed.ncbi.nlm.nih.gov/21265583/
3. https://www.drugs.com/pradaxa.html
4. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ba74e3cd-b06f-4145-b284-5fd6b84ff3c9