Safely Buy Plavix with Aspirin ( Clopidogrel/Aspirin ) from Canada Prescriptions Plus.

Indications

Plavix, also known as clopidogrel, is a medication used to prevent blood clots in individuals who have recently had a heart attack, stroke, or certain heart-related conditions. Aspirin, on the other hand, is a commonly used medication to prevent blood clots, reduce inflammation, and relieve pain.

When it comes to using Plavix with aspirin, there is evidence to suggest that combining these two medications can provide additional benefits in certain cases.

Several studies have shown that the combination of Plavix and aspirin can be more effective than aspirin alone in reducing the risk of heart attack and stroke in certain high-risk individuals.

Use and Dosage

Read the Medication Guide provided by your pharmacist before you start taking clopidogrel and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

The dosage and length of treatment are based on your medical condition and response to treatment. If you are taking this medication to prevent clots after a stent implant or other procedure, take this medication with aspirin for many months to years after the procedure (depending on the procedure/type of stent) as directed by your doctor. Consult your doctor for more details and about the risks of stopping early. Keep taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Get medical help right away if you have any signs that this medication is not working, such as symptoms of a new heart attack or stroke (such as chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, trouble speaking, sudden vision changes, confusion).

Side Effects

The most common side effects of aspirin involve the gastrointestinal system and ringing in the ears.

• Gastrointestinal side effects of aspirin
• Ulcers
• Abdominal burning
• Pain
• Cramping
• Nausea
• Gastritis
• Serious gastrointestinal bleeding
• Liver toxicity

Sometimes, ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding.

The daily dose of aspirin should be reduced if you have ringing in the ears (tinnitus).

Other side effects of aspirin include:

• Rash
• Kidney impairment
• Vertigo
• Dizziness

Other side effects and adverse reactions of aspirin

• People with peptic ulcers or poor kidney function should avoid taking aspirin since it can aggravate both conditions.
• Aspirin may exacerbate asthma.
• Aspirin can raise the blood uric acid level and is avoided in patients with hyperuricemia and gout.
• Children and teenagers should avoid aspirin for symptoms of the flu or chickenpox because of the associated risk of Reye’s syndrome, a serious disease of the liver and nervous system that can lead to coma and death.
• Aspirin can increase the effect of medicines used to treat diabetes mellitus, resulting in abnormally low blood sugars if blood sugar levels are not monitored.

Plavix side effects

The tolerability of clopidogrel is similar to that of aspirin. Common side effects of clopidogrel are:

• Diarrhea
• Rash
• Itching
• Abdominal Pain
• Headache
• Chest Pain
• Muscle aches
• Dizziness

More serious side effects of Plavix include:

• Severe bleeding
• Allergic reactions
• Pancreatitis
• Liver failure

Cautions

• Before taking clopidogrel, tell your doctor or pharmacist if you are allergic to it or similar antiplatelet drugs (thienopyridines such as prasugrel) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding conditions (such as stomach ulcers, bleeding in the brain/eye), recent surgery, serious injury/trauma, liver disease, and bleeding disease (such as hemophilia).
• To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.
• Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor may instruct you to stop clopidogrel for at least 5 days before surgery. Do not stop taking clopidogrel without talking with your heart doctor (cardiologist) first.
• This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk of stomach bleeding. Limit alcoholic beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink.
• During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
• It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Forms and Strengths

Plavix with Aspirin is available in the following forms and strengths:

• Clopidogrel/Aspirin Tablet:
  • 75/75 mg
  • 75/150 mg

FAQ

What is aspirin? How does it work?

Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat fever, pain, and inflammation in the body. It also prevents blood clots and is used to prevent heart attacks and strokes. Other NSAIDs include ibuprofen (Aleve, Motrin), indomethacin (Indocin), and nabumetone (Relafen).

NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins, and reducing levels of inflammation, pain, and fever. Inhibition of prostaglandins also reduces the function of platelets and the ability of blood to clot. Aspirin inhibits the function of platelets in a manner different from other NSAIDs and its antithrombotic effects last longer than other NSAIDs.

What is Plavix? How does it work?

Plavix (clopidogrel bisulfate) is an anti-platelet drug used to prevent blood clots. Plavix is used to reduce the risk of heart attacks and strokes, particularly in people with a recent history of stroke or heart attack, and those with peripheral vascular disease.

Plavix works by binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors. Other P2Y12 inhibitors include ticagrelor (Brilinta) and prasugrel (Effient). Clopidogrel is similar to ticlopidine (Ticlid) in chemical structure and in the way it works.

Can aspirin and Plavix be taken together?

Yes, the combination of clopidogrel and aspirin is better than aspirin or clopidogrel alone in preventing another heart attack, but the risk of bleeding is higher.

Resources:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486024/
2. https://www.medicinenet.com/aspirin_vs_plavix/drug-vs.htm
3. https://www.webmd.com/drugs/2/drug-5869/plavix-oral/details