Safely Buy Norpramin ( Desipramine ) from Canada Prescriptions Plus.

Indications

Norpramin is a brand name for the medication desipramine, which belongs to a class of medications called tricyclic antidepressants.

Norpramin’s main use is to treat depression by restoring the balance of certain natural substances in the brain.

Norpramin may be used to treat other conditions, as determined by a doctor.

Use and Dosage

Read the Medication Guide provided by your pharmacist before you start taking desipramine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually 1 to 3 times daily. The dosage is based on your medical condition and response to treatment. Your doctor may start you at a low dose and gradually increase your dose. This medication may make you sleepy or wakeful. Depending on how this medication affects you, your doctor may direct you to take the entire dose once daily either in the morning or at bedtime.

Follow your doctor’s instructions carefully. Do not take more or less medication or take it more often than prescribed. Your condition will not improve any faster and your risk of side effects will increase. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Keep taking this medication even if you feel well. Do not suddenly stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased.

This medication does not work right away. It may take 2 to 3 weeks before you experience the full benefits when this medication is used for depression.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Serious side effects include:

• Easy bruising, unusual bleeding, or purple or red spots under your skin
• A light-headed feeling, like you might pass out
• Confusion, hallucinations, or unusual thoughts or behavior
• Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
• New or worsening chest pain
• Pounding heartbeats or fluttering in your chest
• Sudden numbness or weakness, problems with vision, speech, or balance
• Fever or sore throat
• Easy bruising or unusual bleeding (nose, mouth, vagina, or rectum)
• Painful or difficult urination
• Upper stomach pain, loss of appetite, or jaundice (yellowing of the skin or eyes)
• A seizure
• Severe nervous system reaction–very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, or feeling like you might pass out

Seek medical attention right away if you have symptoms of serotonin syndrome, such as agitation, hallucinations, fever, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are ill or debilitated.

Common side effects of desipramine may include:

• Increased blood pressure
• Tingly feeling, weakness, and lack of coordination
• Dry mouth, loss of appetite, nausea, or vomiting
• Breast swelling (in men or women)
• Weight gain or weight loss

This is not a complete list of side effects and others may occur.

Cautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as imipramine, amitriptyline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic bronchitis), personal or family history of glaucoma (angle-closure type), diabetes, eating disorders (such as bulimia), heart problems (such as arrhythmias, coronary artery disease, heart attack), liver problems, kidney problems, personal or family history of other mental/mood conditions (such as bipolar disorder, schizophrenia), seizures, overactive thyroid (hyperthyroidism), trouble urinating (such as due to enlarged prostate), any condition that may increase your risk of seizures (including alcohol/sedative dependency, use of electroconvulsive therapy, brain injury/disease such as stroke), certain types of tumors (such as pheochromocytoma, neuroblastoma).

Desipramine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, and fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using desipramine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using desipramine safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug may make you dizzy, drowsy, or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

If you have diabetes, this drug may make it harder to control your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Older adults may be more sensitive to the side effects of this drug, especially dizziness (more likely when standing up), drowsiness, constipation, trouble urinating, mental/mood changes (such as confusion, agitation) and heart effects such as QT prolongation (see above). Dizziness, drowsiness, and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when needed. Infants born to mothers who have taken similar medications during pregnancy may have symptoms such as trouble urinating, prolonged sleepiness, shaking, and seizures. Discuss the risks and benefits with your doctor.

Since untreated mental/mood problems (such as depression, and panic disorder) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Form and Strengths

Norpramin is available in the following form and strengths:

• Desipramine Tablet:
  • 10 mg
  • 25 mg
  • 50 mg
  • 75 mg

FAQ

What happens if I miss a dose?

Take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention. An overdose of desipramine can be fatal.

Overdose symptoms may include irregular heartbeats, feeling like you might pass out, seizures, or coma.

What should I avoid while taking desipramine?

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with desipramine.

Avoid driving or hazardous activity until you know how desipramine will affect you. Your reactions could be impaired.

Avoid exposure to sunlight or tanning beds. Desipramine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Resources:

1. https://www.drugs.com/mtm/desipramine.html#side-effects
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/014399s069lbl.pdf
3. https://www.webmd.com/drugs/2/drug-6936/norpramin-oral/details