Safely Buy Metaglip ( Glipizide/metformin hydrochloride ) from Canada Prescriptions Plus.

Indications

Metaglip is a medication used in the management of type 2 diabetes and is a combination of two oral antihyperglycemic drugs called glipizide and metformin.

Glipizide belongs to a class of drugs known as sulfonylureas, which stimulate the release of insulin from the pancreas and help lower blood sugar levels. Metformin is a biguanide that works by reducing the production of glucose in the liver and improving the body’s response to insulin.

Metaglip is typically prescribed along with a proper diet and exercise program to control high blood sugar levels in people with type 2 diabetes. Follow your healthcare provider’s instructions regarding dosage and usage.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once or twice a day with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Colesevelam can decrease the absorption of glipizide. If you are taking colesevelam, take this product at least 4 hours before taking colesevelam.

Use this medication regularly to get the most benefit from it. Remember to use it at the same time(s) each day.

Tell your doctor if your condition lasts or gets worse (for example, if you have high/low blood sugar). It may take up to 2 weeks before the full benefit of this drug takes effect.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Serious side effects include:

• Heart problems– swelling, rapid weight gain, or feeling short of breath
• Severe hypoglycemia–extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, or seizure
• Lactic acidosis–unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired

Common side effects of glipizide and metformin may include:

• Upset stomach, nausea, or diarrhea
• Headache
• Cold symptoms such as stuffy nose, sneezing, or sore throat

This is not a complete list of side effects and others may occur.

Cautions

• Before taking this medication, tell your doctor or pharmacist if you are allergic to glipizide or metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: alcohol use, severe breathing problems (such as obstructive lung disease, severe asthma), blood problems (such as anemia, vitamin B12 deficiency), electrolyte imbalance (hyponatremia), fertility problems (such as ovulation problems), kidney disease, certain hormonal conditions (adrenal/pituitary insufficiency, thyroid disease, syndrome of inappropriate antidiuretic hormone-SIADH).
• Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop this medication for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure.
• You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Forms and Strengths

Metaglip is available in the following forms and strengths:

• Glipizide/Metformin Hydrochloride Tablet:
  • 2.5/500 mg
  • 5/500 mg

FAQ

What happens if I miss a dose?

Take your dose as soon as you can, but only if you are getting ready to eat a meal. If you skip a meal, skip the missed dose, and wait until your next meal.

What happens if I overdose?

Seek emergency medical attention. An overdose can cause severe hypoglycemia or lactic acidosis.

What should I avoid while taking glipizide and metformin?

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

If you also take colesevelam, avoid taking it within 4 hours after you take glipizide and metformin.

Resources:

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021460s007lbl.pdf
2. https://www.webmd.com/drugs/2/drug-64323/metaglip-oral/details
3. https://www.drugs.com/mtm/glipizide-and-metformin.html#side-effects