Safely Buy Janumet ( Sitagliptin/Metformin ) from Canada Prescriptions Plus.

Indications

Janumet XR is a prescription medication that contains a combination of two drugs, sitagliptin and metformin hydrochloride, used to treat type 2 diabetes. It is an extended-release tablet intended to be taken once daily, to improve glycemic control in adults with type 2 diabetes mellitus.

Consult with a healthcare provider before taking Janumet XR or any other prescription medication.

Use and Dosage

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using sitagliptin/metformin each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily with a meal, preferably in the evening. Swallow the tablets whole. Do not crush or chew the tablets. Doing so can release all the drug at once, increasing side effects risk. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended. Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low).

Side Effects

Common side effects of Janumet:

• Nausea
• Dizziness
• Headache
• Vomiting
• Metallic taste in the mouth
• Fatigue or weakness
• Constipation
• Diarrhea
• Stomach upset
• Muscle pain
• Joint pain

The side effects brought about by this diabetic medication are typically mild and will disappear in a few days. In case the adverse effects persist or worsen, call your doctor or any healthcare provider.

Severe side effects include:

• Signs of lactic acidosis (stomach symptoms that return or occur after the first days of treatment)
• Signs of hypoglycemia (sudden sweating, blurred vision, shaking, fast heartbeat, dizziness, or tingling of the hands and feet)
• Signs of hyperglycemia (thirst, confusion, increased urination, or fruity breath odor)
• Shortness of breath
• Change in urine output
• Unusual skin blisters
• Sudden weight gain
• Persistent vomiting
• Severe stomach pain
• Loss of appetite

This is not a complete list of Janumet’s side effects.

Cautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to sitagliptin or metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, severe breathing problems (such as obstructive lung disease, severe asthma), liver disease, a disease of the pancreas (pancreatitis), stones in your gallbladder (gallstones), blood problems (such as anemia, vitamin B12 deficiency).

Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop this medication for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure.

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase your risk of developing lactic acidosis, pancreatitis, and low blood sugar.

High fever, “water pills” (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause dehydration and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.

Older adults may be more sensitive to the side effects of this drug, especially low blood sugar or lactic acidosis.

Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.

During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.

Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).

Metformin passes into breast milk. It is unknown if sitagliptin passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Janumet is available in the following form and strengths:

• Janumet Tablet:
  • 50/500 mg
  • 50/850 mg
  • 50/1000 mg
• Sitagliptin/Metformin Tablet:
  • 50/1000 mg

FAQ

Is this medication safe?

Clinical trials have proven that this antidiabetic drug is safe and effective.

How long does it take for Janumet to work?

This drug starts working within 5 days of regular use.

What is the difference between Janumet and Janumet XR?

Janumet XR is an extended-release version of Janumet that is only taken once a day.

Does this medication cause weight gain?

An increase in weight is a rare adverse effect of this medication. Consult your doctor if you notice sudden and unusual weight gain while taking this drug.

Resources:

1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50
2. https://www.webmd.com/drugs/2/drug-159466/janumet-xr-oral/details
3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/202270s003lbl.pdf