Safely Buy Entresto ( Sacubitril/Valsartan ) from Canada Prescriptions Plus.

Indications

Entresto is a heart medication that combines sacubitril with valsartan used to improve symptoms of chronic heart failure and reduce the risk of heart failure and death. By combining two drugs, this medication affects two pathophysiological mechanisms of heart failure to help maintain proper blood pressure and flow.

Sacubitril is a blood pressure medication that inhibits neprilysin, which is an enzyme responsible for degrading vasoactive peptides. Valsartan is an angiotensin receptor blocker that blocks the activation of the renin-angiotensin-aldosterone system. All this combined helps prevent heart failure and reduce the risk of death.

Compared to other heart medications, Entresto significantly reduces blood pressure and mortality due to heart failure for those with heart failure, reduced ejection fraction, and elevated circulating levels of natriuretic peptides.

Uses and Dosage

The dose of Entresto prescribed will vary depending on the person and condition being treated. Always follow your doctor’s directives.

• Take with or without food at the same time each day
• Swallow the tablet whole
• Adults usually take 24/26mg up to 97/103mg twice daily
• Doses are determined by weight for children
• Do not take more or less than dose prescribed
• Do not take longer than recommended
• Store away from heat and moisture at room temperature

Side Effects

This medication may cause some side effects as it alters enzymes and chemicals in your blood. Speak with your doctor for more information and advice regarding any Entresto side effects that may occur.

Common Entresto side effects include:

• Kidney problems
• High potassium
• Dizziness
• Feeling light-headed
• Coughing

Serious Side Effects

Some more serious side effects may occur when taking Entresto. Stop using it and seek medical attention if you notice any of the following:

• Light-headed feeling like you might pass out
• Extreme tiredness
• High potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling)
• Kidney problems (little or no urinating, painful or difficult urination, swelling in feet or ankles, feeling tired or short of breath)

Allergic Reaction

Do not take Entresto if you are allergic to either sacubitril or valsartan, or if you have had an allergic reaction to a blood pressure medication, especially the following:

• An ACE inhibitor (benazepril, captopril, enalapril, fosinopril, lisinopril, and others)
• An ARB (azilsartan, candesartan, eprosartan, irbesartan and others)

Stop using this medication and see your doctor if you notice signs of an allergic reaction.

Entresto allergy symptoms may include:

• Hives
• Difficulty breathing
• Swelling of face, lips, tongue, or throat

Cautions

If you have diabetes, do not combine Entresto with any medication containing aliskiren such as Tekturna or Tekamlo.

Do not take Entresto within 36 hours (a day and a half) before or after taking an ACE inhibitor medication.

Do not take Entresto if you are pregnant; stop using it and tell your doctor if you become pregnant. Sacubitril and Valsartan could harm your unborn baby if you take this medication during your second or third trimester. Avoid taking Entresto while breastfeeding as well.

Consult with your doctor to ensure the safety of Entresto, tell them if you have had any of the following:

• Liver disease
• Diabetes
• Hereditary angioedema
• If you are on a low-salt diet
• If you are dehydrated

You may need to avoid Entresto if you have kidney disease.

Avoid alcohol when taking Entresto; it may lower your blood pressure and cause unwanted side effects.

Do not take potassium supplements or salt substitutes while taking this medication unless directed by a doctor.

Form and Strength

This medication is available in film coated tablet form.

Entresto tablet strengths:

• Sacubitril 24mg / valsartan 26mg
• Sacubitril 49mg / valsartan 51mg
• Sacubitril 97mg / valsartan 103mg

The 24/26mg film coated tablets are available in quantities of 84 and 168. The 49/51mg and 97/103mg tablets come in groups of 56 and 168.

FAQ

How long does it take for Entresto to work?

When you take Entresto, its sacubitril and valsartan are broken down and absorbed into your body. The concentration of these drugs stays level and consistent after 3 days of taking the medication twice daily. However, the timeline for visible effects of the drug will vary by person.

Does Entresto improve ejection fraction?

Entresto has been proven to increase left ventricular ejection fraction. The medication does so thanks to its combination of angiotensin receptor antagonist and neprilysin inhibitor that improve blood flow and pressure.

Is Entresto a blood thinner and does it lower blood pressure?

Entresto is not classified as a blood thinner, but it does help lower blood pressure by relaxing blood vessels and improving blood flow. This medication does that through angiotensin receptor blockage and neprilysin inhibition through its combination of valsartan and sacubitril.

Resources:

1. https://pubmed.ncbi.nlm.nih.gov/29532764/
2. https://pubmed.ncbi.nlm.nih.gov/33004114/
3. https://pubmed.ncbi.nlm.nih.gov/26976916/
4. https://www.drugs.com/entresto.html