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Trintellix

Prescription Required
Formulation : Film Coated Tablet
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Vortioxetine

Prescription Required
Formulation : Film Coated Tablet
Drug Name Dosage Quantity Price Buy Now
Vortioxetine 10mg 100 $126.20 Add To Cart
Vortioxetine
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Indications

Trintellix is an antidepressant medication used to treat major depressive disorder (MDD).

Vortioxetine is a serotonergic antidepressant that increases the neurotransmission of serotonin, noradrenaline, dopamine, cholesterol, histamine, and glutamine. These chemicals impact symptoms of MDD and are likely supported by Trintellix’s actions on neuronal activity and receptors.

Trintellix is easily absorbed and generally well tolerated with symptoms functioning like selective serotonin reuptake inhibitors.

Uses and Dosage

The dose of Trintellix prescribed will vary depending on the individual and condition being treated. Always read packaging labels carefully and listen to your doctor’s instructions.

  • Take with or without food
  • Swallow tablet whole
  • Most start by taking 10mg once daily
  • Adults should not take more than 20mg daily
  • Do not double dose
  • Store at room temperature away from moisture and heat

Side Effects

Trintellix may cause some side effects while it helps balance the chemicals in your brain. Speak with your doctor for more information regarding any symptoms you may encounter when taking vortioxetine.

Common Trintellix side effects:

  • Nausea
  • Constipation
  • Vomiting

Tell your doctor if you develop any changes in mood or behaviour such as anxiety, panic attacks, trouble sleeping, if you feel impulsive, irritable, agitated, hostile, hyperactive, more depressed, or have suicidal thoughts.

Serious Side Effects

Some more serious side effects may occur when taking Trintellix. Stop using this antidepressant and call your doctor if you notice any of the following symptoms:

  • Racing thoughts, decreased need for sleep, unusual risk-taking behaviour
  • Feeling extreme happiness or sadness, being more talkative
  • Vision changes, eye pain
  • Eye redness or swelling
  • Easy bruising, unusual bleeding, coughing blood
  • Low sodium levels (confusion, memory problems, hallucinations, slurred speech, severe weakness, feeling unsteady)

Low sodium levels may be more common for older adults.

Seek immediate medical attention if you develop symptoms of serotonin syndrome. These include: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Allergic Reactions

Do not use Trintellix if you are allergic to vortioxetine. If you develop signs of an allergic reaction, stop using this antidepressant and call your doctor.

Trintellix allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling in face, lips, tongue, or throat

Cautions

Wait 14 days before taking Trintellix if you use an MAO inhibitor such as isocarboxazid, methylene blue injection, phenelzine and more. After taking your last Trintellix dose, you must wait at least 21 days before using an MAO inhibitor.

Tell your doctor if you use stimulant medicine, opioid medicine, herbal products, or medication for depression, Parkinson’s disease, migraines, serious infections, or preventing nausea and vomiting. These types of medications could interact with vortioxetine and cause serotonin syndrome, a serious condition.

To ensure the safety of taking this antidepressant, tell your doctor if you have ever had any of the following:

  • Bipolar disorder
  • History of drug abuse or suicidal thoughts
  • Glaucoma
  • Seizures or epilepsy
  • Bleeding problems
  • Low sodium levels in your blood

Some medications can interact with vortioxetine and cause adverse effects. Tell your doctor about all the medications you take, but especially the following:

  • Other antidepressants
  • Buspirone
  • Fentanyl, tramadol
  • Lithium
  • St. John’s wort, tryptophan
  • Diuretic
  • Migraine medicine
  • Nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen, and more)
  • Seizure medication (carbamazepine, phenytoin, and others)

Avoid driving or performing tasks requiring alertness until you know how Trintellix will affect your thinking and reactions.

When taken in the last 3 months of pregnancy, Trintellix may cause complications with the newborn such as withdrawal symptoms or lung problems. Stopping the medicine may cause more problems; do not stop taking Trintellix without first speaking with your doctor. Ask your doctor before taking this antidepressant while breastfeeding.

Some young people have suicidal thoughts when first using an antidepressant. Monitor changes in mood or behaviour and report them to your doctor. Some symptoms include anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, restless, more depressed, or have suicidal thoughts.

Trintellix should not be given to anyone under the age of 18 without advice from a doctor; it is not an approved treatment for children.

Form and Strength

This medication is available in tablet form.

Trintellix tablet strengths:

  • 5mg
  • 10mg
  • 15mg
  • 20mg

All tablet strengths are available in quantities of 28 or 84, except for the 15mg tablets which are only available in quantities of 84.

FAQ

How long does it take for Trintellix to start working?

Trintellix is easily absorbed by your system, but it may take up to 4 weeks for the antidepressant to take full effect. However, some symptoms may improve within 2 weeks.

Can Trintellix be used for anxiety?

Trintellix is not approved for the treatment of anxiety, but off-label it has been used for those with generalized anxiety disorder (GAD). The medication’s effect on anxiety may be thanks to vortioxetine’s impact on multiple different chemicals including noradrenaline.

Should I take Trintellix in the morning or at night?

Trintellix can be taken at any time of day without losing efficacy. However, if you notice that vortioxetine causes you to become restless or energized, you may want to take your doses in the morning to avoid sleep problems.

Resources:

  1. https://pubmed.ncbi.nlm.nih.gov/29189941/
  2. https://pubmed.ncbi.nlm.nih.gov/25016186/
  3. https://www.drugs.com/trintellix.html
  4. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a5b68e2-14d0-419d-9ec6-1ca97145e838

Additional information

Brand Name:

Trintellix

Scientific Name:

Vortioxetine

Other Names:

Brintellix, Fonksera, Trintellix, Voxitin

Strength(s):

5mg, 10mg, 15mg, 20mg

Quantities Available:

28, 56, 84, 100

Formulation:

Film Coated Tablet