Safely Buy Vfend ( Voriconazole ) from Canada Prescriptions Plus.

Indications

Vfend is an antifungal medicine used to treat infections caused by yeast and certain types of fungus including aspergillosis, esophageal candidiasis, scedosporium, fusarium, and candidemia.

Voriconazole is an antifungal drug that inhibits an aspect of the biosynthesis of fungal ergosterol. By reducing ergosterol in fungal cells, Vfend helps treat and improve your fungal infections. The drug is active against many fungus forms allowing it to treat many types of infections.

Dosage and Administration

The dose of Vfend that is prescribed will vary depending on the individual and severity of their fungal infection being treated. Follow all your healthcare provider’s instructions and read packaging labels carefully to ensure the best results. Do not change your dose or suddenly stop taking this medication without consulting your healthcare provider.

• Swallow tablets whole
• Take one hour before or after a meal
• Continue treatment for the full length of time prescribed, even if you feel well
• Store at room temperature away from children and pets

To treat aspergillosis and serious fusarium and scedosporium infections in adults:

• Adults should start treatment with a loading dose of 400mg twice for the first day
• The following day, adults should start taking maintenance doses
• Most maintenance doses are 200mg twice daily, taken 12 hours apart

To treat pediatric fungal infections:

• Children aged 2 to 12 weighing less than 50kg should take a loading dose of 9mg/kg every 12 hours on the first day of treatment
• Starting the second day, children under 50kg should take 9mg/kg up to 350mg every 12 hours
• Children weighing 50kg or more and those 15 or older should take a loading dose of 400mg every 12 hours followed by 200mg every 12 hours each day thereafter

Side Effects

Vfend may cause you to develop some side effects while affecting the growth and spread of fungal cells in your body. Speak with your healthcare provider to learn more about any symptoms you may encounter.

Common Vfend side effects:

• Fever, chills, stuffy nose, sneezing, sinus pain, sore throat
• Cough, difficulty breathing
• Bruising or bleeding, nosebleeds, coughing blood
• High or low blood pressure
• Fast heartbeat
• Electrolyte imbalance
• Stomach pain, bloating, nausea, vomiting, diarrhea, constipation
• Kidney problems
• Swelling hands or feet
• Headache, dizziness, vision changes, hallucinations
• Rash
• Abnormal liver function tests

Serious Side Effects

Some more serious adverse reactions may occur during treatment with Vfend. Call your healthcare provider if you develop any of the following symptoms:

• Fast or pounding heartbeats, fluttering sensation in your chest
• Shortness of breath
• Sudden dizziness
• Sunburn
• Vision problems, changes in your colour vision
• Easy bruising, unusual bleeding
• Purple or red spots under your skin
• Slow heart rate, weak pulse, fainting, slow breathing
• Increased adrenal gland hormones (hunger, weight gain, swelling, skin discolouration, slow wound healing, sweating, acne, increased body hair, mood changes, muscle weakness, missed menstrual periods, sexual changes)
• Decreased adrenal gland function (stomach pain, decreased appetite, light-headedness, muscle or joint pain, skin discolouration, craving salty foods)
• Kidney problems (little or no urination, swollen feet or ankles)
• Liver problems (nausea, vomiting, flu-like symptoms, itchiness, tiredness, jaundice)
• Electrolyte imbalance (dizziness, numbness, tingling, constipation, increased thirst or urination, irregular heartrate, coughing or chocking, feeling jittery, leg cramps, muscle spasms, weakness, limp feeling)

Allergic Reactions

Do not take Vfend if you are allergic to voriconazole or dairy. Stop using this medication and contact your healthcare provider if you develop any of the following signs of an allergic reaction:

• Hives
• Difficulty breathing
• Swelling of your face or throat
• Fever
• Sore throat
• Burning eyes, skin pain
• Red or purple rash
• Blistering or peeling skin

Seek immediate medical attention if you develop signs of a serious drug reaction. Symptoms may include:

• Skin rash
• Fever
• Swollen glands
• Muscle aches
• Severe weakness
• Unusual bruising
• Jaundice

Cautions

• Do not take Vfend if you are pregnant because the medication could cause harm to your baby.
• To ensure your safety when taking Vfend, tell your healthcare provider if you have ever had any of the following:
  • Heart disease
  • Heart rhythm disorder
  • High or low calcium, potassium, or magnesium levels
  • Liver or kidney disease
  • Trouble digesting dairy products
• Avoid driving or performing hazardous tasks until you know how this medication will affect you because Vfend could cause vision changes.
• Wear sunglasses during the day to protect your eyes because Vfend could cause you to become more sensitive to light.
• Vfend can make you more sensitive to sunlight and could cause you to develop skin reactions to the sun if you are exposed to direct sunlight or artificial UV rays for too long. Wear protective clothing and sunscreen while outside.
• Ask your healthcare provider if it is safe for you to breastfeed while taking Vfend.
• Vfend may cause an increase in side effects when used with certain birth control pills. Consult with your healthcare provider about the best form of birth control for you during treatment.
• Many drugs could interact with Vfend and cause adverse reactions. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:
  • Carbamazepine
  • Cisapride
  • Efavirenz
  • Ivabradine
  • Lurasidone
  • Naloxegol
  • Pimozide
  • Quinidine
  • Rifabutin, rifampin
  • Ritonavir
  • Sirolimus
  • St. John’s wort
  • Tolvaptan
  • Venetoclax
  • Some barbiturates such as mephobarbital or phenobarbital
  • Ergot migraine medications like ergotamine or ergonovine
• Vfend is not an approved treatment for any child under the age of 2.

Form and Strength

This antifungal medication is available in tablet form.

• Vfend tablet strengths:
  • 50mg
  • 200mg

Both the 50 and 200mg Vfend tablet strengths are available in quantities of 30.

FAQ

Why should you take Vfend on an empty stomach?

It is recommended that you take your doses of Vfend an hour before or after eating. This is because food can delay your body’s absorption of the medication and reduces its concentrations. Follow all your healthcare provider’s instructions during treatment for the best therapeutic response.

How many days should I take Vfend?

For most conditions you should continue taking your doses of Vfend for at least 14 days. Ensure that you take this medication exactly as prescribed for the entire length of time prescribed, even if you feel well. Your symptoms may improve before your infection is completely clear and stopping treatment early.

Resources:

1. https://www.drugs.com/vfend.html
2. https://www.pfizer.ca/files/Vfend_PM_EN_272725_05-Jul-2023.pdf
3. https://www.pfizer.ca/files/Vfend_PI_EN_272725_05-Jul-2023.pdf
4. https://labeling.pfizer.com/showlabeling.aspx?id=618