Safely Buy Anafranil SR ( Clomipramine ) from Canada Prescriptions Plus.

Indications

Anafranil SR is a medication that contains the active ingredient clomipramine hydrochloride.

Anafranil SR is a sustained-release formulation of clomipramine, which is a tricyclic antidepressant.

Anafranil SR is primarily used to treat symptoms of obsessive-compulsive disorder (OCD), such as recurrent thoughts or feelings and repetitive actions.

Use and Dosage

Read the Medication Guide provided by your pharmacist before you start taking clomipramine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor. To lessen side effects such as stomach upset, clomipramine may be started at a low dose, given in several doses during the day with meals, and slowly increased as your body gets used to it. After you have reached the best dose for you, the total dose can be taken once daily as directed by your doctor, usually at bedtime to prevent daytime drowsiness.

Follow your doctor’s instructions carefully. Do not take more or less of the medication or take it more often than prescribed. Your condition will not improve any faster and your risk of side effects such as seizures may be increased. The dosage is based on your medical condition and response to treatment.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Use this medication regularly to get the most benefit from it. Keep taking it even if you feel well. To help you remember, use it at the same time(s) each day.

Do not suddenly stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is abruptly stopped. You may experience sweating, dizziness, nausea, vomiting, headache, or irritability if you suddenly stop taking this drug. Your dose may need to be gradually decreased.

It may take 2 to 3 weeks or longer before the full effects of this medication are noticed. Inform your doctor if your condition lasts or gets worse.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Report any new or worsening symptoms to your doctor, such as mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Serious side effects include:

• Low sodium level –headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, or feeling unsteady
• Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
• Confusion, extreme fear, or thoughts of hurting yourself
• Pain or burning when you urinate
• A seizure (convulsions)

Seek medical attention right away if you have symptoms of serotonin syndrome, such as agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of clomipramine may include:

• Feeling dizzy, drowsy, tired, or nervous
• Tremors or jerking muscle movements
• Sweating
• Changes in appetite or weight
• Urination problems
• Vision changes
• Decreased sex drive, impotence, or difficulty having an orgasm

This is not a complete list of side effects and others may occur.

Cautions

• Before taking clomipramine, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as imipramine, or nortriptyline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, blood problems (such as purpura, thrombocytopenia), breathing problems (such as asthma, chronic bronchitis), personal or family history of glaucoma (angle-closure type), eating disorders (such as bulimia), heart problems (such as arrhythmias, coronary artery disease, recent heart attack), intestinal problems (such as chronic constipation, ileus), liver problems, kidney problems, personal or family history of other mental/mood conditions (such as bipolar disorder, schizophrenia), history of hospitalization for a very serious reaction to certain medications (neuroleptic malignant syndrome), heartburn/stomach acid in the esophagus (such as due to hiatal hernia), seizures, overactive thyroid (hyperthyroidism), trouble urinating (urinary retention, enlarged prostate), any condition that may increase your risk of seizures (such as alcohol/sedative dependency, use of electroconvulsive therapy, brain injury/disease), certain types of tumors (such as pheochromocytoma, neuroblastoma).
• Clomipramine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, and fainting) that need medical attention right away.
• The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using clomipramine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
• Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using clomipramine safely.
• This drug may make you dizzy, drowsy or temporarily blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
• Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
• Older adults may be more sensitive to the side effects of this drug, especially bleeding, confusion, dizziness, and QT prolongation (see above). Dizziness and confusion can increase the risk of falling. Older adults may also be more likely to develop low sodium in the blood, especially if they are taking “water pills” (diuretics).
• During pregnancy, this medication should be used only when needed. Newborns exposed to clomipramine during pregnancy may experience withdrawal symptoms or side effects. Discuss the risks and benefits with your doctor. Tell your doctor right away if you notice jitteriness, shaking, feeding problems, fast breathing, or seizures in your newborn.
• Since untreated mental/mood problems (such as obsessive-compulsive disorder, depression, and panic attacks) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.
• This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Forms and Strengths

Anafranil SR is available in the following forms and strengths:

• Anafranil SR ER Tablet:
  • 75 mg
• Clomipramine ER Tablet:
  • 75 mg

FAQ

What happens if I miss a dose?

Take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention. An overdose of clomipramine can be fatal.

Overdose symptoms may include irregular heartbeats, feeling restless or agitated, confusion, severe sweating, slow or jerky muscle movements, extreme drowsiness, slow breathing, feeling like you might pass out, seizure, or coma.

What should I avoid while taking clomipramine?

Avoid drinking alcohol. Dangerous side effects could occur.

Avoid driving or hazardous activity until you know how clomipramine will affect you. Your reactions could be impaired.

Resources:

1. https://www.webmd.com/drugs/2/drug-1776/anafranil-oral/details
2. https://www.drugs.com/mtm/clomipramine.html#side-effects
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930847/