Safely Buy Rapamune ( Sirolimus ) from Canada Prescriptions Plus.

Indications

Rapamune is a transplant medication used to prevent organ rejection in patients receiving kidney transplants.

Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor that suppresses T-lymphocyte activity that occurs after antigenic and cytokine stimulation which stops the progression of the cell cycle and installs an immunosuppressive complex. These inhibitory actions allow rapamune to protect against organ rejection for those receiving kidneys and other allograft transplants by preventing your immune system from attacking new organs.

Uses and Dosage

The dose of Rapamune that is prescribed will vary depending on the individual being treated. Follow all your doctor’s instructions carefully to ensure the best results while taking sirolimus.

• Swallow tablets whole
• Can be taken with or without food but take Rapamune the same way each day
• Adults with low to moderate immunologic risk tend to take a maintenance dose of 2mg daily
• Maintenance doses should be preceded with a loading dose three times the amount, for example, 2mg once daily should be preceded by one dose of 6mg
• Patients with high immunologic risk are recommended to take Rapamune with cyclosporine and corticosteroids for 12 months after transplantation
• For combined therapy, patients should start by taking a loading dose of 15mg the day after transplantation, starting day two they should take 5mg once daily
• Doses can be adjusted after 7 to 14 days of maintenance doses
• When taking cyclosporine, wait at least 4 hours before taking your dose of Rapamune
• Do not take more or less than prescribed by your doctor
• Do not stop taking Rapamune or other anti-rejection medicines unless directed by your doctor
• Store at room temperature away from children and pets

Side Effects

Rapamune may cause some side effects to develop while suppressing your immune system response to prevent it from attacking your new kidney. Speak with your doctor for more information regarding any symptoms that you may encounter when taking sirolimus.

Common Rapamune side effects:

• High blood pressure
• Stomach and joint pain
• Diarrhea
• Headache
• Fever
• Urinary tract infection
• Low red blood cell counts
• Nausea
• Low platelet count
• High blood sugar levels

Serious Side Effects

Some more serious adverse reactions may occur when taking sirolimus. Stop using Rapamune and contact your doctor right away if you develop any of the following side effects:

• Swelling of hands or feet
• Trouble breathing
• Slow wound healing, redness or drainage of a wound
• Increased cholesterol and triglyceride levels
• Kidney function problems
• Increased protein levels in your urine
• Viral infections
• Unexplained bruising or bleeding

Allergic Reaction

Do not take Rapamune if you are allergic to sirolimus or any of the other listed tablet ingredients. If you develop signs of an allergic reaction, stop using this anti-rejection medication and call your doctor.

Rapamune allergy symptoms may include:

• Swelling of face, eyes, or mouth
• Wheezing or trouble breathing
• Throat tightness
• Chest pain or tight feeling
• Feeling dizzy or faint
• Skin rash or peeling

Cautions

Do not take Rapamune if you have received a lung or liver transplant. This medication is designed to prevent organ rejection in those receiving kidney transplants.

Avoid ingesting any grapefruit products while taking Rapamune because it can interact with sirolimus and cause an increase in adverse effects.

During treatment with Rapamune you should avoid receiving any live vaccines because they may not work as effectively while you are taking sirolimus.

You may be at an increased risk of developing skin cancer while taking Rapamune. During treatment, avoid direct exposure to sunlight and ensure that you use broad spectrum sunscreen when outdoors.

To ensure your safety when taking Rapamune, tell your doctor if you have ever had any of the following:

• Liver problems
• Skin cancer or family history of skin cancer
• High cholesterol or triglyceride levels

Rapamune is an immunosuppressive medication which can leave you more vulnerable to developing serious infections. Contact your doctor for preventative treatment if you come into contact with anyone who is sick or infected.

Some drugs can interact with sirolimus and cause adverse reactions. Tell your doctor about all the medications that you take, including over the counter medicines, but especially any of the following:

• cholesterol or triglyceride lowering medication
• Cyclosporine, tacrolimus, or other immunosuppressive drugs
• Antibiotics
• Antifungal medicine
• Blood pressure or heart medication
• Anti-seizure medicines
• Medications for stomach acid, ulcers, or other gastrointestinal issues
• Bromocriptine mesylate
• Danazol
• Letermovir
• HIV or hepatitis C medications
• St. John’s wort
• Cannabidiol

Sirolimus can cause harm to an unborn baby if taken during pregnancy. Use effective forms of birth control during treatment and for at least 12 weeks after your last dose. Tell your doctor right away if you become pregnant while taking Rapamune.

Do not breastfeed while taking Rapamune because it can pass into your breastmilk and affect your nursing child.

Sirolimus may affect fertility in men and women during treatment. Female patients have reported developing ovarian cysts and menstrual disorders while men have developed azoospernia. These effects are often reversible after stopping treatment with Rapamune.

Rapamune is not approved for use in any children under the age of 13.

Form and Strength

This organ transplant rejection medication is available in tablet form.

Rapamune tablet strengths:

• 1mg
• 2mg

The 1mg Rapamune tablets are available in quantities of 30 and 100 while the 2mg tablets are available in quantities of 90.

FAQ

How does Rapamune prevent rejection?

Rapamune helps prevent organ transplant rejection by inhibiting your body’s immune response and lowering your number of T-lymphocytes which attack new or foreign organs. Thanks to these inhibitory actions, the drug helps prevent rejection following kidney transplants.

What precautions should be taken when taking Rapamune?

You should avoid ingesting any grapefruit products during treatment with Rapamune because it can cause an increase in your blood concentration of sirolimus and lead to adverse reactions. This medication may also increase your risk of developing skin cancer, so it is important to avoid direct exposure to sunlight and UV rays during treatment.

Resources:

1. https://labeling.pfizer.com/ShowLabeling.aspx?id=139&section=MedGuide
2. https://labeling.pfizer.com/ShowLabeling.aspx?id=1187
3. https://www.drugs.com/rapamune.html