Safely Buy Jakavi ( ruxolitinib phosphate ) from Canada Prescriptions Plus.

Indications

Jakavi is a medication used to treat certain types of blood disorders. It contains the active ingredient ruxolitinib and works by blocking certain enzymes in the body.

Jakavi is indicated for the treatment of diseases related to splenomegaly or symptoms in adult patients with primary myelofibrosis, chronic myelomonocytic leukemia, and certain other blood disorders. It is used to treat acute graft versus host disease in patients aged 12 years and above.

Use and Dosage

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor may occasionally change your dose. You will need frequent medical tests to help your doctor determine the best dose.

You may take ruxolitinib with or without food. The ruxolitinib tablet can also be given through a nasogastric (NG) feeding tube.

Read and carefully follow any Instructions for Use provided with the medicine. Ask your doctor or pharmacist if you do not understand these instructions.

If you are on dialysis, ruxolitinib should be taken after your dialysis.

Using ruxolitinib may increase your risk of developing other cancers. Ask your doctor about this risk.

You should not stop using ruxolitinib suddenly. Follow your doctor’s instructions about tapering your dose.

You may be given other medications to help prevent infection. Keep taking these medicines for as long as your doctor has prescribed.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may be similar to the symptoms of myelofibrosis. Call your doctor at once if you have:

• Changes in the size, shape, or color of a mole or skin lesion

Problems with speech, thought, vision, or muscle movement (these symptoms may start gradually and get worse quickly)

• Nausea, vomiting, weakness, or general ill feeling
• Cold sores around your mouth, skin sores or blisters, itching, tingling, skin rash, or burning pain in your thigh or lower back
• Pain in your arms, back, neck, jaw, or stomach
• Signs of a stroke–sudden numbness or weakness, severe headache, slurred speech, or problems with vision or balance
• Signs of a blood clot in the lung–chest pain, sudden cough or shortness of breath, dizziness, or coughing up blood
• Signs of a blood clot deep in the body–pain, swelling, or warmth in one leg
• Heart attack symptoms–chest pain or pressure, pain spreading to your jaw or shoulder, nausea, or sweating
• Signs of infection–fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising, or bleeding
• Low blood cell counts–fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, or feeling light-headed or short of breath
• Signs of tuberculosis–fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired

Common side effects of ruxolitinib may include:

• Low blood cell counts
• Swelling
• Infection
• Bruising
• Diarrhea
• Dizziness
• Headache

This is not a complete list of side effects and others may occur.

Cautions

• You should not use ruxolitinib if you are allergic to it.
• Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also, tell your doctor if you have had or been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.
• Tell your doctor if you have or have ever had:
  • Any type of infection
  • Shingles (herpes zoster)
  • A blood clot, stroke, heart attack, or other heart problems
  • Low white or red blood cell counts
  • Any type of cancer
  • Are a current or past smoker
  • Kidney disease (or if you are on dialysis)
  • Liver disease (especially hepatitis B)
  • High cholesterol or triglycerides (types of fat in the blood)
• It is not known if ruxolitinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
• Do not breastfeed while using ruxolitinib, and for at least 2 weeks after your last dose.
• Ruxolitinib is not approved for the treatment of myelofibrosis or polycythemia vera by anyone younger than 18 years old.

Form and Strengths

Jakavi is available in the following form and strengths:

• Jakavi Tablet:
  • 5 mg
  • 10 mg
  • 20 mg

FAQ

What happens if I miss a dose?

Take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid while taking ruxolitinib?

Grapefruit may interact with ruxolitinib and cause side effects. Avoid consuming grapefruit products.

Resources:

1. https://www.drugs.com/mtm/ruxolitinib.html#before-taking
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202192lbl.pdf